5′ Trials COPERNICUS (Carvedilol) | carvedilol คือ

You are viewing this post: 5′ Trials COPERNICUS (Carvedilol) | carvedilol คือ

5′ Trials COPERNICUS (Carvedilol)

ชมวิดีโอด้านล่าง

นอกจากการดูบทความนี้แล้ว คุณยังสามารถดูข้อมูลที่เป็นประโยชน์อื่นๆ อีกมากมายที่เราให้ไว้ที่นี่: ดูเพิ่มเติม

Toda sextafeira temos o expresso “5’Trials”, que faz uma exposição breve (em no máximo 5 minutos) dos principais artigos publicados na história da cardiologia mundial!
O artigo comentado de hoje é o COPERNICUS publicado no New England Journal of Medicine em 2001, que avaliou o uso do Carvedilol em pacientes com Insuficiência Cardíaca avançada.
Artigo Original: DOI: 10.1056/NEJM200105313442201
Sugestões e comentários em [email protected]
Siga o @cardiolearning no instagram
Edição:
Dr. Brenno Rizerio
Dra. Bruna Scarpa
Dr. Francisco Akira
Dr. Mozar Suzigan
Dr. Vagner Madrini
Idealização:
Dr. Brenno Rizerio
Dr. Vagner Madrini

Carvedilol For The Treatment of Heart Failure and High Blood Pressure – Overview

ชมวิดีโอด้านล่าง

http://www.rxwiki.com/carvedilol
https://www.youtube.com/playlist?list=PLXxn_pCvHVm6N7v1BzNqFYiJYYwRKymPQ
Carvedilol is a prescription medication used to treat heart failure and high blood pressure. Carvedilol belongs to a group of drugs called beta blockers. These work by relaxing blood vessels and decreasing the heart rate to improve blood flow and reduce blood pressure.
This medication comes in tablet form and is taken twice a day with food.
Common side effects of carvedilol include low blood pressure, weight gain, and fatigue. Carvedilol can also cause dizziness. Do not drive a car or operate machinery until you know how carvedilol affects you. Take this medication only as directed. For more information, download the RxWixi mobile app

Beta Blockers Mechanism Of Action [peopranolol, antenolo, bisoprolol, carvedilol]

ชมวิดีโอด้านล่าง

beta blockers are one of the most important classes of medications that are primarily used to treat cardiovascuar disease.
Beta blockers are indicated and have FDA approval to treat tachycardia, hypertension, myocardial infarction, congestive heart failure, cardiac arrhythmias as well as hyperthyroidism and even migraine prophylaxis.
starting with an overview of beta receptors, they exist in the body in 3 distinct forms, Beta 1, 2 and 3
beta 1 is located primarily in the heart and mediates cardiac activity, Beta 2 however exists throughout the body in many organ systemscontrol various aspects of metabolic activity and induce smooth muscle relaxation. Beta3 receptors induce the breakdown of fat cells and are less clinically relevant at present.
to understand the mechanism of action of beta blockers, we have to understand how do betaadrenocetors work, in this figure we can see how the heart has both B1 and B2 receptors, although predominantly B1, these receptors normally bind to adrenaline and noradrenaline released from the nerve ending or the circulating in the blood. beta receptors are coupled with Gs protein, which activates adenylyl cyclase to form cAMP from ATP, increased cAMP activates cAMP dependent protein kinase (PKA) that phosphorylates Ltype calcium channels, which causes increased calcium entry into the cells. the increased calcium entry during action potential leads to increased inotropy or contractility.
now that we understand how the receptor works, it’s easy for us to understand the result of blocking the receptor in patients with mycardial infarction witch results in relaxation of the heart muscle.
Betablockers classify as either nonselective and beta1 selective. Nonselective agents bind to both beta1 and beta2 receptors and induce antagonizing effects via both receptors. Examples include propranolol, carvedilol, sotalol, and labetalol. Beta1 receptorselective blockers like atenolol, bisoprolol, metoprolol, and esmolol only bind to the beta1 receptors; therefore, they are cardioselective
Beta receptors are found all over the body and induce a broad range of physiologic effects. The blockade of these receptors with betablocker medications can lead to many adverse effects. Bradycardia and hypotension are two adverse effects that may commonly occur. Fatigue, dizziness, nausea, and constipation are also widely reported. Some patients report sexual dysfunction and erectile dysfunction. All betablockers, especially in patients with cardiac risk factors, carry a risk of heart block.
it’s worth mentioning that beta blockers are contraindicated in asthmatic patients, that’s why it’s recommended that only beta1 selective beta blockers can be administered to asthmatics.

Farmacología: Carvedilol

ชมวิดีโอด้านล่าง

Farmacología
Grupo 2201
Elaboró: Morales Ruiz Abraham de Jesús Created using Powtoon Free sign up at http://www.powtoon.com/youtube/ Create animated videos and animated presentations for free. PowToon is a free tool that allows you to develop cool animated clips and animated presentations for your website, office meeting, sales pitch, nonprofit fundraiser, product launch, video resume, or anything else you could use an animated explainer video. PowToon’s animation templates help you create animated presentations and animated explainer videos from scratch. Anyone can produce awesome animations quickly with PowToon, without the cost or hassle other professional animation services require.

How To Say Carvedilol

ชมวิดีโอด้านล่าง

Learn how to say Carvedilol with EmmaSaying free pronunciation tutorials.
Definition and meaning can be found here:
https://www.google.com/search?q=define+Carvedilol

นอกจากการดูหัวข้อนี้แล้ว คุณยังสามารถเข้าถึงบทวิจารณ์ดีๆ อื่นๆ อีกมากมายได้ที่นี่: ดูบทความเพิ่มเติมในหมวดหมู่GENERAL NEWS

Articles compiled by CASTU. See more articles in category: GENERAL NEWS